The American Heart Association and American College of Cardiology recognize twelve factors that can raise ASCVD risk beyond traditional cholesterol and blood pressure measures. These include: family history of premature ASCVD, persistently elevated LDL-C (≥160 mg/dL), chronic kidney disease, metabolic syndrome, inflammatory diseases (like rheumatoid arthritis, psoriasis, HIV), conditions specific to women (preeclampsia, premature menopause), South Asian ancestry, persistently elevated triglycerides (≥175 mg/dL), high-sensitivity C-reactive protein (hs-CRP)>> (≥2.0 mg/L), lipoprotein(a) (Lp(a)) (>50 mg/dL), low ankle-brachial index (ABI) (<0.9), and chronic inflammation from conditions such as psoriasis.