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October 29, 2025

It's All Connected: What is CKM Syndrome? The Silent Risk Affecting Millions

Cardiovascular-Kidney-Metabolic (CKM) syndrome is a silent condition linking heart, kidney, and metabolic health. Millions are at risk without knowing it, especially in groups like South Asians. Early screening and prevention are key to stopping its progression.

Awareness
Science

Introduction: A Hidden Thread in Everyday Health

Meet Arjun. At 45, he feels healthy. He works a demanding but rewarding job, enjoys weekend hikes with his family, and mostly watches what he eats. His blood pressure is a little high, an issue his doctor has mentioned, and his father had type 2 diabetes, but Arjun feels fine. He has no symptoms, no pain, and no reason to worry.

Or so he thinks.

What Arjun doesn’t know is that these seemingly disconnected facts, “elevated” blood pressure and a family history of diabetes, are potential warning signs of a newly defined but widespread health issue: Cardiovascular-Kidney-Metabolic (CKM) syndrome. This condition links heart and circulatory disease, kidney disease, and metabolic disorders like diabetes and obesity into a single, unified syndrome.

And CKM syndrome is silent. By the time symptoms appear, significant damage may have already been done.

What is CKM Syndrome?

For decades, heart disease, kidney disease, and conditions like type 2 diabetes were treated separately, often by different specialists. But in 2023, the American Heart Association confirmed what many doctors already knew: these systems are deeply interconnected.

CKM syndrome is the name for this connection. Think of your cardiovascular, kidney, and metabolic systems as a three-legged stool. If one leg is weak, the whole stool becomes unstable.

Here’s how it works:

  • Metabolic Health: The foundation. When your metabolism isn’t working well due to excess fat or insulin resistance, it raises the sugar and unhealthy fat levels in your blood. These damage blood vessels.
  • Cardiovascular Health: Impaired metabolic health can also lead to high blood pressure, further straining your heart and blood vessels, leading to heart attacks, strokes, or heart failure.
  • Kidney Health: Kidneys rely on healthy vessels to function well and filter waste. High blood pressure and blood sugar damage them, leading to chronic kidney disease and kidney failure.

This isn’t one-way. A struggling heart can’t pump enough blood to the kidneys, making them weaker. Failing kidneys can’t regulate blood pressure, straining the heart even more. It’s a vicious cycle where each system drags the others down.

Why It’s the Silent Risk

The most dangerous aspect of CKM syndrome is how quietly it develops. In early stages, you feel normal. No symptoms. Yet blood sugar may be rising, plaque may be building in arteries, and kidneys may already be under stress.

This lack of awareness is a massive public health challenge.

  • 90% of US adults are already CKM Stage 1 or higher.
  • One in three U.S. adults has at least three risk factors for CKM-related disease.
  • Many people don’t get screened for kidney function.
  • Routine check-ups may catch blood pressure or cholesterol, but rarely look at all three systems together.
  • When elevated blood pressure or blood sugar are caught early, they can be reversed to prevent developing hypertension and diabetes.

Without proactive screening, the first sign of CKM can be something catastrophic like a heart attack or stroke.

Why It Matters for Millions

CKM syndrome isn’t a niche issue. It’s a global epidemic hiding in plain sight. While it affects everyone, certain groups face much higher risk.

High-Risk Populations

  • South Asians, Southeast Asians, and Middle Eastern populations are especially vulnerable.
    • Higher insulin resistance makes it harder for their bodies to manage blood sugar.
    • They store more visceral fat (around organs) rather than subcutaneous fat. This type of fat is highly inflammatory and drives CKM.
    • They face risk at a lower BMI. A South Asian person with a BMI of 24 may have the same risk as a Caucasian person with a BMI of 30.

South Asians, for example, are up to four times more likely to develop heart disease and have higher rates of chronic kidney disease.

Other groups, including Black and Hispanic/Latino individuals, also face elevated risks due to higher rates of high blood pressure, diabetes, and obesity.

How It Progresses: The Stages of CKM

The AHA created a staging system to help track CKM progression. The goal is prevention: stop people from moving to the next stage.

  • Stage 0: No Risk Factors
    Perfect health. The goal is to stay here.
  • Stage 1: Early Risk
    Excess body fat or prediabetes. Problems are beginning to form.
  • Stage 2: Moderate Risk
    Clear metabolic issues: type 2 diabetes, high blood pressure, high triglycerides, or early kidney disease.
  • Stage 3: High Risk
    Silent cardiovascular disease shows up in tests—plaque buildup in your arteries or early signs of heart failure. Kidney disease is often advancing.
  • Stage 4: Very High Risk
    Major cardiovascular events like heart attack, stroke, or heart failure occur, usually alongside significant kidney disease.

Knowing your stage is the first step toward taking control. The earlier you act, the more you can slow or even reverse progression.

What You Can Do

CKM Syndrome is serious, but not inevitable. Small steps and early action make a big difference.

1. Get Screened

  • Ask for BMI, blood pressure, cholesterol, blood sugar, and kidney function tests.
  • Don’t wait for symptoms—screening catches issues early.

2. Focus on Prevention

  • Follow the American Heart Association’s Life’s Essential 8, which also includes:
    • Choose balanced meals with vegetables, whole grains, and lean proteins.
    • Stay active. Aim for at least 30 minutes of movement most days.
    • Prioritize sleep and manage stress.

3. Know Your Risk

  • Be proactive if you have a family history of CKM conditions.
  • If you’re in a higher-risk group, consider earlier and more frequent screenings.

4. Partner with Your Healthcare Team

  • Prevention isn’t one-size-fits-all.
  • Work with your doctor to build a plan that fits your health, culture, and lifestyle.
“CKM Syndrome may be silent, but your choices can speak loudly in your favor.”

Your Health is Connected. Your Care Should Be Too.

CKM Syndrome is all about connection: the hidden thread between the heart, kidneys, and metabolism. By understanding it, we can break the cycle of late diagnosis and preventable illness.

At Porter Health, we’re here to make prevention simpler, smarter, and more accessible. Whether it’s through health assessments, CKM risk screening, or culturally tailored resources, our mission is to help families, especially those in high-risk groups, take control before CKM takes hold.

Don’t wait for symptoms. Start with awareness. Start with screening. Start today.

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